成像技巧等类MRI,PET,spect并微信can provide insights into safety liabilities through administration of the test compound in a longitudinal fashion. This allows the preclinical animal to serve as its own control and offer a method of non invasively understanding drug distribution profiles using techniques such as PET and SPECT to determine site of action with respect to on or off target effects. In combination with anatomical and functional parameters achieved using MRI, micro CT and PET it is possible to accurately determine efficacy vs the side effects associated with off target effects. Essentially, within the same animal, it is possible to determine biodistribution, efficacy and toxicity at the earliest opportunity either at the lead optimisation stage or during safety assessment conducted in life as opposed to the reliance on conventional time point analysis of ex vivo tissue.
维吾尔成像技术越来越多地用于确定majo